Dr. Rahman’s laboratory research efforts focus on identifying novel immunotherapy approaches to overcome resistance in patients with high grade glioma. She collaborates with Dr. Duane Mitchell and many other investigators in the UF Brain Tumor Immunotherapy Program. Her training in neurosurgical oncology and tumor stem cell biology has provided her the foundation to investigate several novel immunotherapy strategies for patients with brain cancer. Dr. Rahman’s laboratory team includes Dr. Aida Karachi (DVM, PhD) and Dr. Farhad Dastmalchi (DVM). They are actively working in the following areas:
- Immunomodulation using various dosing schemes of chemotherapy to synergize with immunotherapy including immune checkpoint inhibitors
- Tracking immune cells in vivo after implantation using metabolic profiling in collaboration with Southeast Center for Integrated Metabolomics (SECIM)
- Improving migration of immune cells after vaccination using small molecules
- Monitoring immune response after immunotherapy in patients with brain cancer using metabolic changes induced in the serum and urine
Dr. Rahman’s work is supported by grants from the NIH, the Preston A. Wells Jr. endowment and private foundations. Her translational research is actively being tested in human clinical trials.