Special Interests
- Immunotherapy
- Immunology
Biography
Dr. Jianping Huang is a professor of neurosurgery at the University of Florida and has extensive experience in cancer immunotherapy studies. She spent a decade at the National Cancer Institute (NCI), where she joined the Surgery Branch in 2002 under the esteemed leadership of Dr. Steven A. Rosenberg. There, she developed deep expertise in human immunology and a profound dedication to cancer immunotherapy. In 2009, Dr. Huang advanced to become the Head of the Molecular Immunology Group at the Laboratory of Tumor Immunology and Biology (LTIB), NCI. In this role, she directed numerous studies in basic tumor immunology, evaluated clinical trials, and developed novel strategies for cancer immunotherapy. During her tenure at NCI, Dr. Huang conducted pivotal research and led efforts to characterize effective antitumor T cells for clinical trials, focusing on the phenotype and function of human T cells for adoptive immunotherapy. Her work was instrumental in identifying tumor-specific antigens associated with clinical responses.
In December 2013, Dr. Huang joined the Department of Neurosurgery at the University of Florida. Since then, she has achieved significant milestones, including obtaining FDA approval (IND#23881) for clinical trials using IL-8 receptor-modified CD70CAR (8R-70CAR) T cells (NCT 05353530), which are currently recruiting patients with glioblastoma (GBM). Additionally, her team has made pioneering discoveries, such as identifying and developing Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1 or CD305) antibody blockade, creating a novel 3-in-1 CAR T cell therapy, and advancing several other cancer therapeutic approaches. Dr. Huang’s contributions to cancer immunotherapy are further highlighted by multiple patents, which hold substantial potential for clinical translation. Her innovative work continues to advance the understanding and application of immunotherapy in the fight against cancer.
List of Dr. Huang’s major publications: https://www.ncbi.nlm.nih.gov/myncbi/jianping.huang.2/bibliography/public/