Clinical Trials

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The development of more effective treatments requires that new and innovative therapies be evaluated in patients. The Department of Neurosurgery at the University of Florida provides patients who have brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage, and other disorders with opportunities to participate in clinical trials. Additionally, the Preston A. Wells, Jr. Center for Brain Tumor Therapy focuses on basic, translational, and clinical research in the areas of primary and metastatic brain tumors. Clinical trials are research studies designed to evaluate the safety and effectiveness of new drugs or treatment strategies.

122957-RE-MATCH-brain-graphicThe information gained from clinical trials is essential for improving survival, quality of life, and higher standards of care. Ideas for clinical trials usually come from researchers. After researchers test new therapies or procedures in the laboratory and in animal studies, the experimental treatments with the most promising results are moved into clinical trials. During a trial, more and more information is gained about an experimental treatment, its risks and how well it may or may not work. Clinical trials are sponsored or funded by a variety of organizations or individuals such as physicians, medical institutions, foundations, voluntary groups, and pharmaceutical companies, in addition to federal agencies such as the National Institutes of Health (NIH), the Department of Defense (DOD), and the Department of Veteran’s Affairs (VA). Trials can take place in a variety of locations, such as hospitals, universities, doctors’ offices, or community clinics. Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research. To learn more about our available clinical trials for brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage and other disorders, please review the clinical trial listings below.


Current Clinical Trials

Brain Tumors

Clinical Trial IDDescription
ACTIONAdoptive Cellular Therapy following Dose-Intensified Temozolomide in Newly-diagnosed Pediatric High-grade Gliomas
Contact: Marcia Hodik, 352-273-9000
BRAVOBRAVO: Newly-Diagnosed Brain Stem Gliomas Treated with Adoptive Cellular Therapy during Recovery from Focal Radiotherapy Alone or Radiotherapy and Dose-intensified Temozolomide
Contact: Marcia Hodik, 352-273-9000
SJMB12A Clinical and Molecular Risk-directed Therapy for Newly Diagnosed Medulloblastoma
Contact: Jennifer King, 352-273-9000
20171046Phase Ib/II Clinical Trial of Nivolumab Monotherapy and Nivolumab in Combination with Ipilimumab in Pediatric Subjects with High Grade Primary CNS Malignancies
Contact:Ā Jennifer King, 352-273-9000
HeadStart 4Newly Diagnosed Children (Less than 10 Years Old) With Medulloblastoma and Other Central Nervous System Primitive Neuro-Ectodermal Tumors: Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with Either Single-Cycle (Low Risk Patients) or Randomization (High Risk Patients) to either Single-Cycle or to Three Tandem Cycles of Marrow-Ablative Chemotherapy with Autologous Hematopoietic Progenitor Cell Rescue
Contact: Jennifer King, 352-273-9000
PNOC 001Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children
Contact: Jennifer King, 352-273-9000
PNOC 002Safety, Phase 0, and Pilot Efficacy Study of Vemurafenib, an Oral Inhibitor of BRAFV600E, in Children and Young Adults with Recurrent/Refractory BRAFV600E- or BRAF Ins T mutant Brain Tumors
Contact: Jennifer King, 352-273-9000
20171323A Phase 2 Clinical Study of Pomalidomide (CC-4047) Monotherapy for Children and Young Adults with Recurrent or Progressive Brain Tumors
Contact: Jennifer King, 352-273-9000
Re-MATCHRecurrent Medulloblastoma and Primitive Neuroectodermal Tumor Adoptive T Cell Therapy during Recovery from Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation.
Contact: Marcia Hodik, 352-273-9000
ATTAC-IIA Phase II Randomized, Blinded, and Placebo-controlled Trial of CMV RNA-Pulsed Dendritic Cells with Tetanus-Diphtheria Toxoid Vaccine in Patients with Newly-Diagnosed Glioblastoma
Contact: Phuong Deleyrolle, 352-273-9000
2-THE-TOPPhase 2, Single Arm, Historically Controlled Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (OptuneĀ®) Plus Pembrolizumab in Patients with Newly Diagnosed Glioblastoma
Contact: Sonisha Warren 352-273-900
201500287A Phase II Study of the Optune System, Enhanced by Genomic Analysis to Identify the Genetic Signature of Response in the Treatment of Recurrent Glioblastoma Multiforme
Contact: Sonisha Warren 352-273-9000
201600074A Phase 2, Multi-center, Single arm, Histologically Controlled Study Testing the Combination of TTFields and Pulsed Bevacizumab Treatment in Patients with Bevacizumab-refractory Recurrent Glioblastoma
Contact: Sonisha Warren 352-273-9000
201500336A Phase I and Open Label, Randomized, Controlled Phase II Study Testing the Safety, Toxicities, and Efficacy of MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant
Gliomas
Contact: Sonisha Warren 352-273-9000
Tg 511-15-01A Phase 2/3 Randomized, Open-Label Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC versus Standard of Care in Subjects Undergoing Planned Resection for Recurrent Glioblastoma or Anaplastic Astrocytoma
Contact: Sonisha Warren 352-273-9000
CODELPhase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma
Contact: Sonisha Warren 352-273-9000
STELLARA Phase 3, Randomized, Open-Label Study To Evaluate the Efficacy and Safety of Eflornithine with Lomustine Compared to Lomustine Alone in Patients with Anaplastic Astrocytoma That Progress/Recur After Irradiation and Adjuvant Temozolomide Chemotherapy
Contact: Sonisha Warren 352-273-9000

Cerebral Aneurysms

ASTROHAneurysmal Subarachnoid Hemorrhage Trial Randomizing Heparin: A Prospective, Randomized, Phase IIA Pilot Study of Unfractionated Heparin in aSAH
Contact: Jessica Smith, 352-273-9000
FEATFraming Eighteen coils in cerebral Aneurysms
Contact: Jessica Smith, 352-273-9000
NANOEffectiveness and Safety of Small Aneurysm Coiling Trial
Contact: Ashley Lockerman, 352-273-9000

Related Links

  • ClinicalTrials.gov is a registry of federally and privately supported clinical trials conducted in the United States and around the world.
  • The National Cancer Institute’s registry of available clinical trials, clinical trial results, and educational materials.

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