Location: Room L2-160, McKnight Brain Institute
Director: Brian Hoh, MD
About the Lab
Dr. Hoh’s laboratory performs research investigating: 1) the biologic mechanisms for aneurysm formation and rupture using a mouse model of intracranial aneurysms; 2) the mechanisms by which hemodynamic stress at bifurcations cause inflammation that leads to aneurysm formation using in vitro cell culture flow models; 3) the development of biologic and tissue-engineered therapies for the treatment of aneurysms using a murine carotid aneurysm model; and 4) the identification of cytokines and factors responsible for aneurysm formation and rupture using human cerebral aneurysm tissue. Dr. Hoh’s laboratory consists of a faculty associate scientist (Koji Hosaka, MD); a research technologist; graduate students, medical students, and post-doctoral trainees.
Dr. Hoh laboratory has received numerous grants from the NIH, Brain Aneurysm Foundation, American Association of Neurologic Surgeons Neurosurgery Research and Education Foundation, Thomas Maren Foundation, and others.
Selected laboratory publications:
- Hoh BL, Hosaka K, Downes DP, Nowicki KW, Fernandez CE, Batich CD, Scott EW. Monocyte chemotactic protein-1 promotes inflammatory vascular repair of murine carotid aneurysms via a macrophage inflammatory protein-1α and macrophage inflammatory protein-2-dependent pathway. Circulation. 2011 Nov 15;124(20):2243-52. doi: 10.1161/CIRCULATIONAHA.111.036061. Epub 2011 Oct 17. PMID: 22007074; PMCID: PMC3217188.
- Hosaka K, Rojas K, Fazal HZ, Schneider MB, Shores J, Federico V, McCord M, Lin L, Hoh B. Monocyte Chemotactic Protein-1-Interleukin-6-Osteopontin Pathway of Intra-Aneurysmal Tissue Healing. Stroke; a journal of cerebral circulation. 2017;48(4):1052-60. Epub 2017/03/16. doi: 10.1161/strokeaha.116.015590. PubMed PMID: 28292871; PMCID: PMC5390817.