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Clinical Trials


The development of more effective treatments requires that new and innovative therapies be evaluated in patients. The Department of Neurosurgery at the University of Florida provides patients who have brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage, and other disorders with opportunities to participate in clinical trials. Additionally, the Preston A. Wells, Jr. Center for Brain Tumor Therapy focuses on basic, translational, and clinical research in the areas of primary and metastatic brain tumors. Clinical trials are research studies designed to evaluate the safety and effectiveness of new drugs or treatment strategies.

122957-RE-MATCH-brain-graphicThe information gained from clinical trials is essential for improving survival, quality of life, and higher standards of care. Ideas for clinical trials usually come from researchers. After researchers test new therapies or procedures in the laboratory and in animal studies, the experimental treatments with the most promising results are moved into clinical trials. During a trial, more and more information is gained about an experimental treatment, its risks and how well it may or may not work. Clinical trials are sponsored or funded by a variety of organizations or individuals such as physicians, medical institutions, foundations, voluntary groups, and pharmaceutical companies, in addition to federal agencies such as the National Institutes of Health (NIH), the Department of Defense (DOD), and the Department of Veteran’s Affairs (VA). Trials can take place in a variety of locations, such as hospitals, universities, doctors’ offices, or community clinics. Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research. To learn more about our available clinical trials for brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage and other disorders, please review the clinical trial listings below.

Current Clinical Trials

Brain Tumor

Re-MATCH Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor Adoptive T Cell Therapy during Recovery from Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation. Contact: Marcia Hodik, 352-273-9000
FCBTR Establishment of a UF Brain Tumor Tissue Bank: Florida Center for Brain Tumor Research.Contact: Barbara Frentzen, 352-273-9000
126-2013 Dendritic Cell (DC) and Tumor-Specific Cytotoxic T Cell (CTL) Generation Protocol from Healthy Volunteers and Patients with Malignant Brain Tumors.  Contact: Nina McGrew, 352-273-9000
201300710 InterSPORE Multicenter Specimen Collection Feasibility Study. Contact: Nina McGrew, 352-273-9000

Cerebral Aneurysm

FEAT Framing Eighteen coils in cerebral Aneurysms Trial Contact: Adrienne Royster, 352-273-9000
LARGE LARGE Aneurysm Randomized Trial: Flow Diversion Versus Traditional Endovascular Coiling Therapy Contact: Adrienne Royster, 352-273-9000
SCENT The Surpass Intracranial Aneurysm Embolization System Pivotal Trial to Treat Large or Giant Wide Neck Aneurysms Contact: Adrienne Royster, 352-273-9000


201300797 Association between Haptoglobin Genotype and the Development of Perihematomal Edema after Spontaneous Intracerebral Hemorrhage. Contact: Adrienne Royster, 352-273-9000
014-2013 Sample Repository for Studying Brain Injuries. Contact: Adrienne Royster, 352-273-9000
201400503 Finding the Genes that Predispose to Trigeminal Neuralgia.  Contact: Joseph Pittman, 352-273-9000

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