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Clinical Trials


The development of more effective treatments requires that new and innovative therapies be evaluated in patients. The Department of Neurosurgery at the University of Florida provides patients who have brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage, and other disorders with opportunities to participate in clinical trials. Additionally, the Preston A. Wells, Jr. Center for Brain Tumor Therapy focuses on basic, translational, and clinical research in the areas of primary and metastatic brain tumors. Clinical trials are research studies designed to evaluate the safety and effectiveness of new drugs or treatment strategies.

122957-RE-MATCH-brain-graphicThe information gained from clinical trials is essential for improving survival, quality of life, and higher standards of care. Ideas for clinical trials usually come from researchers. After researchers test new therapies or procedures in the laboratory and in animal studies, the experimental treatments with the most promising results are moved into clinical trials. During a trial, more and more information is gained about an experimental treatment, its risks and how well it may or may not work. Clinical trials are sponsored or funded by a variety of organizations or individuals such as physicians, medical institutions, foundations, voluntary groups, and pharmaceutical companies, in addition to federal agencies such as the National Institutes of Health (NIH), the Department of Defense (DOD), and the Department of Veteran’s Affairs (VA). Trials can take place in a variety of locations, such as hospitals, universities, doctors’ offices, or community clinics. Participants in clinical trials can play a more active role in their own health care, gain access to new research treatments before they are widely available, and help others by contributing to medical research. To learn more about our available clinical trials for brain and spinal cord conditions such as brain tumors, cerebral aneurysms, stroke, carotid stenosis, subarachnoid hemorrhage and other disorders, please review the clinical trial listings below.

Current Clinical Trials

Contact: Adrienne Royster, 352-273-9000

Brain Tumor

Re-MATCH Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor Adoptive T Cell Therapy during Recovery from Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation.
Contact: Marcia Hodik, 352-273-9000
STML-701-0114 Title:  A Phase 1/2 Study of SL-701, a Subcutaneously Injected Multivalent Glioma-Associated Antigen Vaccine, in Adult Patients with Recurrent Glioblastoma Multiforme
Contact: Adrienne Royster, 352-273-9000
Tg 511-15-01 A Phase 2/3 Randomized, Open-Label Study of Toca 511, A Retroviral Replicating Vector, Combined with Toca FC versus Standard of Care in Subjects Undergoing Planned Resection for Recurrent Glioblastoma or Anaplastic Astrocytoma
Contact: Adrienne Royster 352-273-9000
201500336 A Phase I and Open Label, Randomized, Controlled Phase II Study Testing the Safety, Toxicities, and Efficacy of MK-3475 in Combination With MRI-guided Laser Ablation in Recurrent Malignant
Contact: Adrienne Royster 352-273-9000
201400876 A Shortened Antiepileptic Drug (AED) Course in Surgical Brain Tumor Patients: A Randomized Trial.
Contact: Nina McGrew, 352-273-9000
FCBTR Establishment of a UF Brain Tumor Tissue Bank: Florida Center for Brain Tumor Research.
Contact: Barbara Frentzen, 352-273-9000
201500637 Dendritic Cell (DC) and Tumor-Specific Cytotoxic T Cell (CTL) Generation Protocol from Healthy Volunteers and Patients with Malignant Brain Tumors.
Contact: Nina McGrew, 352-273-9000
201300710 InterSPORE Multicenter Specimen Collection Feasibility Study.
Contact: Nina McGrew, 352-273-9000

Cerebral Aneurysm

FEAT Framing Eighteen coils in cerebral Aneurysms
Contact: Jessica Smith, 352-273-9000
NANO Effectiveness and Safety of Small Aneurysm Coiling Trial
Contact: Ashley Lockerman, 352-273-9000


NV-APL001 Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study
Contact: Jessica Smith, 352-273-9000
201400503 Finding the Genes that Predispose to Trigeminal Neuralgia.
Contact: Joseph Pittman, 352-273-9000

Related Links

  • is a registry of federally and privately supported clinical trials conducted in the United States and around the world.
  • The National Cancer Institute’s registry of available clinical trials, clinical trial results, and educational materials.

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